Menifee is a city in Riverside County, California, United States, and part of the Los Angeles Combined Statistical Area. The city is centrally located in the heart of Southern California, in the Menifee Valley. It is almost 15 miles (24 km) north of Temecula and just north of Murrieta. Menifee is roughly 46 square miles (100 km ²) in size and has an elevation of 1,424 feet (434 m). The incorporated City of Menifee includes the communities of Sun City, Quail Valley, Paloma Valley, and Romoland.

The city of Menifee is bordered on the north, west, south and east by the cities of Perris, Canyon Lake, Lake Elsinore, Wildomar, Murrieta, and the community of Winchester. The city center of Menifee lies at the intersection of Newport Road and Interstate 215.

According to the United States Census Bureau, the city covers an area of 46.6 square miles (120.7 km ²), 99.70% of it land, and 0.30% of it water.